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When areas of the body are subject to ongoing inflammation, many issues can arise

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Iron released via HMOX1 activated the iron-dependent histone demethylase KDM6B, driving the expression of myeloid cell-associated proteins which promoted recruitment of immunosuppressive myeloid-derived suppressor cells and tumor-associated macrophages (TAMs) to the tumor site [59]

Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer