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Metabolomic analyses have also revealed significant alterations in branched-chain AAs (BCAAs), including isoleucine, leucine, and valine, in serum and plasma of patients with IBD [22, 23, 26]

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Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance

Without wanting to be bound by theory, the reason is that protein formulations can be physically stabilized by selecting formulation pH values that are sufficiently different from the isoelectric point of the molecule in order to favor electrostatic repulsion as described herein