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8 Additionally, while TMAO affects endothelial barrier function, it can also act on various types of cells, including vascular smooth muscle cells, epithelial cells, pancreatic cells, neurons, astrocytes, microglia, and oligodendrocytes, thereby exerting broad impacts on numerous human diseases

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For example, SDC2-SEPTIN9-BCAT1 combined with ctDNA methylation demonstrates high sensitivity and specificity (Xu et al., 2021)

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