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Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation

10.1016/j.psj.2021.101622 86

Several approaches may be considered in developing drugs for reversing aberrant DNA methylation like inhibition of the universal methyl group donor SAM, downregulation of methyl-CpG binding domain (MBD) proteins and inhibition of DNMT enzymes (3538)

Cell Death Differ 11(Suppl 1):S73S85 Gallogly MM, Starke DW, Mieyal JJ (2009) Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation

37:e99259

PMID: 28587019