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The SCALE phase 3a trials discussed in this paper were designed prior to the recent regulatory requirements for intercurrent events and hence patients discontinuing randomized injections or violating the protocol were withdrawn from the trials and only invited in for a landmark visit to assess the body weight

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Adult Detrusor Overactivity Associated With a Neurologic Condition In clinical trials, 30.6% of adult patients (33/108) who were not using CIC prior to injection required catheterization for urinary retention following treatment with BOTOX 200 Units, as compared to 6.7% of patients (7/104) treated with placebo