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The substrate solution was then added and incubated in the dark at RT for 15 min, after which the reaction was stopped with the provided stop solution

34 Prx2 activity is mainly sustained by Trx/TR and ultimately NADPH from the PPP

Similarly, BioNTechs mRNA-based BNT153 and BNT152, encoding IL-2 and IL-7, respectively, are in a Phase I trial (NCT04710043) for advanced solid tumors (200)

SPINDOC (SPIN1 docking protein) and KIF18B (Kinesin family member 18B) have also been shown to be overexpressed in HCC and can similarly play a role in promoting the proliferative, invasive, and metastatic capacities of HCC cells through activation of this pathway (132, 133)

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doi: 10.3390/metabo12111145 33 MustafaS.AkbarM.KhanM