glutathione and napqi A 48-hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https://bestpractice.bmj.com/topics/en-us/1010 5️⃣ Antidote: NAC (N-acetylcysteine) NAC

5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N acetyl meta aminophenol (AMAP) Archives of Toxicology Springer Nature Link Solved The following figure shows the metabolism of the NAPQI an overview ScienceDirect Topics Critical care toxicology for acetaminophen overdose N Phenylquinoneimine Encyclopedia MDPI

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