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The primary evidence-based interventions remain: Weight loss through caloric restriction and increased physical activity (target 710% body weight reduction) Dietary modification , including reduced sugar and saturated fat intake Management of associated conditions such as diabetes and dyslipidaemia Alcohol : for NAFLD, keep within UK low-risk drinking guidelines (no more than 14 units per week, ideally less or none)

J Immunol 211: 156177

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Macrophage or neutrophil depletion To deplete macrophages, mice were intraperitoneally injected with 1 mg liposomal clodronate or control liposomes (Fisher Scientific, NC1488571) 60

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