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Tumor redox heterogeneity, variations in intracellular GSH levels, and discrepancies between in vitro and in vivo redox environments make precise prediction of therapeutic activation difficult

Among these, the salmon module (Fig

Acknowledgements We acknowledge the help of the staffs at Zhongnan Hospital of Wuhan University in completing the study

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This review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation