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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

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Since then, a large number of studies have shown that Gln addiction exists in many tumours, including cervical cancer, gastric cancer and colon cancer [10, 11]

This approach has significant potential, given the unique vulnerability of cancer cells to oxidative stressa characteristic that can be exploited for therapeutic benefit

Data availability The data supporting the results of this study are available from the corresponding author upon reasonable request

TGR5 is highly expressed in BECs, KCs and LSECs