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A structured diagnostic approach, including clinical evaluation, differential diagnosis, and assessment of therapeutic response when appropriate, is essential to avoid misdiagnosis in elderly patients with cirrhosis, as the response to HE treatment may help confirm the diagnosis (Fig

TMAO synergizes with LPS to enhance the activation of NF-B in DCs and macrophages, increase the production of pro-inflammatory cytokines, and impair the function of Tregs

Free-text questions A free-text question was included to gain a deeper understanding of circumstances around self-medication, Do you have any concerns about safety and self-medication? There were also three other free-text questions relating to the treatment type that they were receiving, treatment frequency, and the effects of the SARSCoV-2 pandemic on their treatment