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Low maternal B12 has been linked to anemia, irreversible neurological changes, and serious birth defects like spina bifida and anencephaly 2

10.1080/01635581.2020.1801777 34 HuM.DuH.XuY.WangY

Landwehrmeyer B

Furthermore, PINK1/Parkin-dependent mitophagy can also be activated by the accumulation of unfolded proteins within the mitochondrial matrix, highlighting a novel trigger beyond mitochondrial depolarization [32]