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Furthermore, AuNPs and AgNPs regulate the nuclear factor-kappa B (NF-B) pathway

The design and application of dual-targeted and multi-targeted inhibitors place a greater emphasis on the interrelations of pathological factors, enhancing the convenience of medication for patients

Targeting VEGF-independent cords A number of different mechanisms, including the upregulation of other angiogenic pathways such as the Notch pathway, have been described to play a role in the development of tumor vessels that are insensitive to anti-VEGF therapy [4, 14, 15, 34]

Depression patients generally exhibit reduced vagal tone and decreased heart rate variability (HRV), suggesting parasympathetic insufficiency

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doi: 10.1016/S0140-6736(21)02251-0 138 WongDPRoyNKZhangKAnukanthAAsthanaAShirkey-SonNJet al