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Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions

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This can lead to: Increased oxidative stress and cellular damage Impaired liver function and detoxification Greater risk of lung inflammation and asthma development Weakened immune response , making it harder to fight off illness A major International Study of Asthma and Allergies in Childhood (ISAAC) involving over 322,000 children across 50 countries found a strong exposure-dependent relationship between acetaminophen use and the development of asthma, rhinoconjunctivitis, and eczema

This raises to great concerns about the safety of nanomaterials, and puts forward higher requirements for the regulation of nanotoxicity