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During AKI, mitochondria frequently exhibit morphological abnormalities, including swelling and fragmentation, which can facilitate the release of pro-apoptotic mediators and trigger the opening of the mitochondrial permeability transition pore

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Research on patient preferences consistently shows overwhelming preference for nasal formulations, with feedback describing them as fastest and simplest. The elimination of needle-related anxiety, pain, and the need for sterile technique significantly reduces barriers to consistent therapy adherence

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