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Thus, dysfunctional carbonylated proteins accumulate as covalently crossed protein aggregates, making them highly resistant to proteolysis, thereby affecting the functional integrity of cells during the aging and disease processes

Lack of insulin receptor signaling in Leprechaunism may result in the rare event of an alive but severely small for gestational age baby that will only survive if treated with recombinant-IGF-1 to substitute inulin receptor signaling with IGF1R signaling via their common intracellular pathways

In many papers (including Yuen TJ, Silbereis JC et al., Cell 2014 cited by the reviewer and the method book chapter entitled Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures , Gorter et al., 2022

Jul 2014;16(7):577-87

and relative elongation of burned part of skin=length burned skin immediately before breaking/initial length of burned skin

speculative claims (e.g., unregistered clinical trials) have been excluded