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Furthermore, the TET2Upf1 complex has been shown to negatively regulate mRNA stability [84]

The implication of these findings is substantial, as it gives the chance to tackle the transition from autoimmunity to inflammation by restoring intestinal barrier function and thereby preventing the onset of RA

Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al

This timing is not arbitrary

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