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doi: 10.3389/fcell.2016.00016 Received 29 November 2015 Accepted 22 February 2016 Published 23 March 2016 Volume 4 - 2016 Edited by Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by Yves Combarnous, Centre National de la Recherche Scientifique, France

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However, unlike these inhibitors, the dimeric form of 6-thio-dG operates through a competitive inhibition mechanism against CDNB (1-chloro-2,4-dinitrobenzene), a standard GST substrate

10.3390/ijms231810669 136 TrutnevaK

Increased levels of MDA also indicate an upsurge in lipid peroxidation, which may lead to significant alterations in cell membrane function and DNA composition, leading to mutation