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Zoeller, Thresholds and endocrine disruptors: an Endocrine Society Policy perspective

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Targeted manipulation of lipid DAMP signaling, macrophage polarization, or T-cell susceptibility to oxidized lipids may unlock the potential of ferroptosis-inducing agents not just as cytotoxic therapies, but as immune modulators capable of tipping the TME toward durable anti-tumor immunity

In addition, baicalein (BAE) and DOX were separately loaded into cationic solid lipid nanoparticles to form BAE-SLN and DOX-SLN, where BAE-SLN was modified with aminoethyl aniline amide (AEAA) to form AEAA-BAE-SLN (ABS) and DOX-SLN was modified with folic acid (FA) to form FA-DOX-SLN (FDS), and both were further encapsulated in carboxymethyl chitosan (CMCS) to form the nanocapsule NPC-ABS/FDS which can enhance CD8 + T and CD4 + T cells infiltration, reduce Tregs, and significantly inhibit tumor growth (165)

It takes almost a month and a half to see results and they only improve from there