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doi: 10.1002/jcb.v120.2 10 WadhwaSKKaziTGAfridiHITalpurFNNaeemullah

Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)

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Clearly, although serum B12 is the most frequently used biomarker of B12 status, the marked variation in the literature for the reference limits and cutoffs said to be indicative of inadequate B12 status, make the diagnosis of B12 deficiency and the provision of prevalence estimates based on serum B12 alone challenging

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