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Without adequate antioxidant protection, these radicals can damage proteins, DNA, and cellular membranes

Lower: Polyamine levels in ALDH18A1 -KO or YG1702 (10 ug/ml)-treated PDLCs and SNU449 cells

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Under the combined influence of inflammatory mediators and oxidative stress, chondrocytes undergo chondroaging, characterized by mitochondrial dysfunction, disordered cellular metabolism, reduced SIRT1 activity, and impaired autophagy

Sarangi, A., Singh, P., Virmani, M., Yadav, A., Sahu, S., Ajithakumar, H

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