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Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)

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however, compared to CAF, PXN has higher binding potency for adenosine A1 and A2A receptors and produces more substantial locomotor activation effects (Orr et al