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For clinicians working in endocrinology, metabolic medicine, or hormone optimization, this combination merits evaluation within a structured clinical framework: comprehensive pre-treatment assessment, individualized dosing based on patient physiology, regular IGF-1 monitoring, and integration with broader hormonal and metabolic management

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The views expressed in this paper are those of the authors and do not necessarily represent the views of the US Department of Veterans Affairs or the US government

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Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumour

Native IGF-1 has 10-20 minute half-life, strong IGFBP binding limiting bioavailability, primarily local autocrine/paracrine actions, and rapid clearance