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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

ChatterjeeRFussPVickeryEMLeBlancESSheehanPRLewisMRet al

NAD+ precursors like nicotinamide riboside (NR) reverse inflammatory and ageing phenotypes in T cell-specific TFAM-knockout mice (Desdn-Mic et al, 2020)