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10.1080/1028415X.2023.2243089 16 AzamS.JakariaM.KimI

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conducted a randomized, double-blind, placebo-controlled study of oral melatonin in COPD patients which showed that melatonin administration reduced oxidative stress and relieved dyspnea (difficulty breathing) [65]

[33] demonstrated that NNMT expression is upregulated in WAT of humans with insulin resistance or T2D and that plasma MNA levels are significantly and positively correlated with NNMT expression in WAT and with the degree of insulin resistance