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However, there is a observational study that propose the opposite conclusion (23)

It is one of the major ceramides in the stratum corneum (outermost layer of skin) plays a role in forming a protective barrier

Summary Laryngopharyngeal reflux represents a common extraesophageal manifestation of gastroesophageal reflux, producing a range of upperairway and throat symptoms that require careful evaluation and integrated management to prevent chronic mucosal damage and functional impairment

The authors acknowledge support from Canadian Institutes of Health Research (CIHR)

Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells