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Although there are evidenced-based data supporting certain treatment approaches for patients in clinical studies, the unsolved question in clinical practice remains: "Who is the ideal patient for a given treatment approach?" Thus, treatment of IC/BPS often requires a trial-and-error approach

5 Overall considerations and future/putative therapies and immunotherapies for MB The MB is an aggressive tumor characterized by a relevant molecular and cellular heterogeneity The advances in genomic and transcriptomic have identified several subtypes within the four subgroups (52, 56, 65, 71, 74, 79, 88, 306)

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