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The distinct chemical microenvironment between the dendrimer core and periphery enables efficient encapsulation of hydrophobic agents with suboptimal pharmacokinetic and pharmacodynamic profiles (114)

For example, the Y390-containing loop is positioned in a manner similar to our original SCF FBXO22 structure with UNC10088 C and NSD2 versus the BACH1-bound structure, suggesting that the two regions function independently to recruit substrates with minimal interference

[17] They named it "lymphadenopathy-associated virus", or LAV, since it was not then clear that it was the cause of AIDS, and published their findings in the journal Science on 20 May 1983

Matrix Biol (2010) 29(6):5118

Effect of -tocopherol in alleviating the lipopolysaccharide-induced acute lung injury via inhibiting nuclear factor kappa-B signaling pathways