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The specificity of the assay was tested using the GCL inhibitor L-buthionine-S, R-sulfoximine

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Free Radic Biol Med 53:16891696 Uchiyama S, Shimizu T, Shirasawa T (2006) CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice

Therapies work better in a stack when they are chosen for a specific reason rather than added because they are well known online

Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)