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In CCs, the unfolded protein response (UPR) resulting from ER stress prompts the activation of PERK/ATF4 signaling that in turn activates a positive feedback loop, upregulating VEGF at the transcriptional level, both by inducing the VEGF promoter and increasing VEGF mRNA stability [119]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Baekdal TA, Borregaard J, Hansen CW, et al

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