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This paper describes possibly the first clinical study to use a hyperpolarized 13 -labelled substrate

10.1128/AEM.00948-21 Appl

Diaz et al

Adding (or removing) a methyl group to a molecule is critical for genetic expression, growth, neurotransmitter production, detoxification, and other critical biochemical processes

131 In line with this notion, defects in TLS polymerases including polymerase (DNA-directed), (POLH) and REV3-like, polymerase (DNA directed), , catalytic subunit (REV3L) have been linked to increased CDDP sensitivity in vitro