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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections

[12] Folate supplementation may affect the course and treatment of pernicious anemia if vitamin B 12 not replaced

Applications encompass investigating cognitive aging, neurodegenerative disease prevention, and brain performance optimization through metabolic enhancement

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These longer cycles require more careful monitoring and may benefit from slight dose reductions in weeks 13-16 to maintain receptor sensitivity

doi:10.1021/acs.bioconjchem.4c00545