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Epidemiological data strongly supports this bidirectional association

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Biochem Pharmacol 52(1):1519 Zhao R, Masayasu H, Holmgren A (2002) Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

By examining the difference in resonance frequency of hydrogen nuclei in difference chemical environments, MRS can distinguish between hydrogen nuclei in different molecules

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