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Moreover, ACE2 can mitigate inflammation by degrading pro-inflammatory Ang II and producing the protective peptide Ang-(1-7) (144)

When these two compounds were incubated in the presence of 10 mM GSH for 6 or 18 h under physiological conditions before adding them into the in vitro kinase assay (PhALC), the IC 50 of JNK-IN-8 drastically dropped but 1a R -IN-8 stayed similarly active in blocking MAPK activity (Fig