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Have more energy, not jittery, and starting to loose some weight

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This places them at elevated risk for B12 deficiency, and standard oral supplementation may not provide adequate absorption

When NNMT is inhibited, nicotinamide remains available for salvage into NAD+ via the NAMPT (nicotinamide phosphoribosyltransferase) pathway

Methylmalonic acid and homocysteine are more sensitive markers of functional deficiency