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(5) the nuclear receptor coactivator of energy expenditure, peroxisome proliferator-activated receptor- coactivator-1 (PGC-1), and its downstream uncoupling protein-1 (UCP-1) ( In addition to the regulation of key metabolic enzymes and transcription factors, emerging evidence suggests that LBPs beneficial effects on glycolipid metabolism are also mediated through epigenetic mechanisms, particularly involving microRNAs (miRNAs), which have been widely documented to exert a specific effect in maintaining glucose homeostasis ( -oxidation of hepatic fatty acids, ultimately reversing IR and abnormal glucose tolerance in HFD-induced GDM mice ( 2.3 LBP restores pancreatic -cell function Insulin, the sole hypoglycemic hormone in the body secreted by pancreatic -cells, is crucially involved in glucose homeostasis (50)