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By engineering an antigen-specific single-chain variable-fragment antibody (scFv) fused to intracellular lymphocyte signaling domains, T cells are functionally redirected to specific surface molecules on tumor cells

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LKB1 activates AMPK and AMPK-related kinases, leading to the upregulation of catabolic pathways and mitochondrial biogenesis, while simultaneously suppressing anabolic processes to maintain this metabolic resting state[15, 46]

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