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Tefera TW, Bartlett K, Tran SS et al (2019) Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis

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Astrocytes immediately respond to any form of CNS insult, exhibiting morphological and functional changes characterized by hypertrophy, enhanced expression of the glial fibrillary acidic protein (GFAP), the release of inflammatory mediators, and the synthesis of neurotrophic factors (Abbracchio and Ceruti, 2006)