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Although Ucp2 knockout mice showed a higher level of cellular ATP production and enhanced GSIS, [86] which tends to support the above idea, two independent studies reported that Ucp2 -ablated fully back-crossed mice failed to show improved GSIS [87, 88]

Oral glutathione is inefficiently absorbed, and therapeutic approaches that only use oral supplements tend to struggle with achieving results

Supplementary material To view supplementary material for this article, please visit Acknowledgement The authors thank Dr Samwel Mchele Limbu, University of Dar es Salaam, Tanzania, and qualified native English-speaking editors at Charlesworth Author Services, for editing the English text of this manuscript

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Meanwhile, miR398b also decreases the activity of APX and CAT, and the contents of GSH as well, leading to H 2 O 2 accumulation (He et al., 2021)