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Nat Med 2013;19:114752

doi: 10.1016/j.jri.2017.09.006 356 Garrido-GmezTCastillo-MarcoNCorderoTSimnC

Characterization of microbial communities from gut microbiota of hypercholesterolemic and control subjects

GPX converts peroxides and hydroxyl radicals to non-toxic forms by oxidizing GSH to glutathione disulfide, which is then reduced to GSH by glutathione reductase ( The antioxidant response is modulated mainly by the Nrf2/Keap1 system (Figure 2)

On microglial cells, the mechanism of AMPK activation through ROS and calcium signaling pathways during P2X7R stimulation, leading to mitochondrial division, induction of mitophagy, and activation of the nuclear transcription factor TFEB has been proven (Sekar et al., 2018)

World J Gastroenterol 12(5):791795 Dias LFT, Melo ES, Hernandes LS, Bacchi EM (2009) Atividades antilcera e antioxidante Baccharis trimera (Less) DC (Asteraceae)