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Kupffer cells and DC, but not B cells in the Rej liver, upregulated PD-L1, PD-L2 and TREM2, a marker of immunosuppressive myeloid cells (Fig F)

She recommends combining two sunblocks, a physical sunscreen, and the other with a chemical sunscreen, to maximize the protection against the suns UV rays

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Sesquiterpenes are agonists of the pregnane X receptor but do not induce the expression of phase I drug-metabolizing enzymes in the human liver

10.1038/ajg.2009.727 [DOI] [PubMed] [Google Scholar] 6

These challenges arise not only from methodological heterogeneity but also from biological complexity, and they must be addressed to enable translation of mechanistic findings into clinical application