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Upon treatment of LPS and IFN- stimulated M1 macrophages with G/D-CuP, the population of M1 macrophages reduced to 36.4% (Fig

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G6PD deficiency is an X-linked disorder

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Finally, selective regulation within the sirtuin family is essential, as overactivation of SIRT1 could disrupt the functional balance of related sirtuins, necessitating careful control of activation intensity and tissue- or subcellular-specific delivery

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