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Mitochondrial dysfunction is a key factor driving epithelial cell death: Drp1-mediated excessive mitochondrial fission leads to ROS accumulation and apoptosis, while steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain-containing protein 7 (STARD7) protects barrier function by maintaining mitochondrial membrane stability [75, 76]

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Priority should be given to well-designed human intervention studies, integrate systems biology approaches, and explore delivery technologies that enhance the stability and targeted action of these molecules