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Drug-induced ferroptosis In 2021, Yang et al (66) reported that cetuximab inhibits the progression of KRAS-mutant CRC through the promotion of RSL3-induced ferroptosis via inhibition of the Nrf2/heme oxygenase 1 (HO-1) signaling pathway

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Concurrently, reduced expression of OXPHOS subunits further impairs mitochondrial electron flow, resulting in decreased m and diminished coupling efficiency