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Unraveling mucin domains in cancer and metastasis: When protectors become predators

Similarly, iridium (III) complexes trigger ferroptosis and autophagy in A549 cells through GSH depletion, MDA/LPO elevation, GPX4/ferritin downregulation, and BECN1-mediated ferritinophagy-all in an HMGB1-dependent manner ( Lung adenocarcinoma (LUAD), the most prevalent NSCLC subtype, often develops resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance and exhibits low immune checkpoint expression

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J Clin Endocrinol Metab 89 : 16131617 Skjaerbaek C et al

In turn, lack of OXPHOS results in accumulation of reducing compounds in and outside the mitochondrial matrix, a condition known as reductive stress 310

Omega-3 and omega-6 PUFA are incorporated into phospholipids, where they not only serve structural roles in cell membranes of the nervous system, but also affect membrane fluidity, flexibility, permeability, as well as the activities of membrane-associated enzymes and receptors (13, 90)