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Glycolysis as a therapeutic target has been well established modality for overcoming therapy induced resistance in preclinical models, however, depending on anaerobic or aerobic conditions, lactate or pyruvate can be the product, respectively

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Promising avenues include EPA in conjunction with statins to target triglyceride-driven risk, CoQ10 supplementation to enhance myocardial energetics in heart failure, and magnesium repletion to reduce arrhythmogenic potential in at-risk populations ( Despite generally favorable tolerability profiles, supplementation is not devoid of risk

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