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47 DiNuzzoM.GioveF.MaravigliaB.MangiaS

[46] It should, however, be noted that although the two enzymes catalyze similar reactions, these generally occur in opposite directions: dihydrolipoyl dehydrogenase uses NAD + to oxidize two SH groups to a disulfide (SS)

The CSD has been demonstrated to be reduced during the process of T-cell signaling, and its reduction is also co-opted during entry of the HIV viral envelope glycoprotein (gp120) into the cell

Nat Commun 9(1):1480

This functional plasticity and heterogeneous nature across tumors, patients, and species complicate their impact on tumor biology, particularly in human malignancies, which present a more complex picture than the predominantly pro-tumorigenic TAM activity observed in rodent models (5, 6)

For those with serious anemia, this medication may rarely cause hypokalemia (low potassium)