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crassa , EGT is synthesized via three enzymatic reactions, which is more efficient than the bacterial pathway (Fig

Ogawa S, Hosoi K, Ikeda N, Makino M, Fujimoto Y, Iida T

Cold Spring Harb Perspect Biol 2012

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Other studies indicate that ATP7B maintains cellular copper homeostasis by transporting copper to the Golgi apparatus for integration into copper-dependent enzymes, NFE2L2 (NRF2) activates various antioxidant enzymes to mitigate oxidative stress and inflammation caused by copper excess, and MTF1 detects abnormal metal concentrations and induces detoxification and stress-response gene expression (170)