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This dual action reduces neuronal apoptosis and promotes functional recovery post-ischemic stroke, offering promise for cell-based therapies in cerebrovascular disorders

Studies showed that procainamide demethylated and re-expressed the RAR2 and p16 genes in urinary bladder carcinoma and breast cancer cells (Cancer Research Technology Ltd, 2007) and the WIF-1 gene in lung cancer cells (Procaine et al., 2009)

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A deep understanding of the pathogenic mechanisms of PD is of crucial importance for overcoming the limitations of current single-target therapies and for developing synergistic treatment strategies capable of simultaneously intervening at multiple key nodes (Fig

However, it is now recognized that much of the increased risk reported in the WHI was attributable to the use of synthetic progestins rather than estrogen itself

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