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doi: 10.3390/antiox11122345 27 HayesJDNaiduSDDinkova-KostovaAT

Expert Opinion on Biological Therapy (2012) 11

These results suggest that upregulation of HO-1 is not an essential component for iron accumulation in the mitochondria and DOX-induced ferroptosis and that downregulation of ABCB8 is not a sufficient mechanism for iron accumulation in the mitochondria after DOX treatment